The Fugate family settled on the banks of Troublesome Creek after 1800. Mary, the wife of the patriarch Martin, was a carrier for a rare disease called hereditary methemoglobinemia.
" Due to an enzyme deficiency, the blood of met-H victims has reduced oxygen-carrying capacity. Instead of being the usual bright red, arterial blood is chocolate brown and gives the skin of Caucasians a bluish cast."Some of the Fugates intermarried with the nearby Smiths clan, one of whom also carried met-H. The first "blue Fugate" was born in 1832, and a bunch of cousins popped up thereafter. There were about 6 in the 1890s, and one was reported as recently as 1975.
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